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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 457254Generated: October 30, 2026

Thionyl Chloride → [(Diphenylmethyl)sulfanyl]acetyl chloride

https://huagongshe.com/reaction/457254

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant2-Benzhydrylsulfanylacetic acidHCID 2077886—
Product[(Diphenylmethyl)sulfanyl]acetyl chlorideHCID 14181405—

Reaction Steps

2-[(Diphenylmethyl)thio]acetic acid (III), on reaction with thionyl chloride yielded the corresponding 2-[(diphenylmethyl)thio]acetylchloride (IV), which on reaction with ammonia produced 2-[(diphenylmethyl)thio]acetamide (I) which on oxidation with hydrogen peroxide resulted in modafinil (II).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07186860B2
Source datasetuspto-grants-2007_03
ORD IDord-c5991789c2934795ba36bdaabc72d005
Source noteuspto-grants-2007_03