Ammonia → HCID 22291565, compound

Participants

Reaction Conditions

Reaction Steps

The title product of Step 3 was dissolved in anhydrous ethanol and then an approximately equal volume of liquid ammonia was added. The resulting mixture was sealed in a pressure vessel and then stirred overnight at 100° C. After cooling, the mixture was concentrated. The residue was taken up in dichloromethane-methanol and chromatographed over silica gel using ethyl acetate as eluent to give the title compound, 890 mg, as an oil which crystallized on standing. Anal. for C19H16N4O3.0.75H2O (MW 361.87): Calc'd.: C, 63.06; H, 4.46, N, 15.48. Found: C, 63.24; H, 4.70, N, 14.58.

Provenance & Evidence