Trifluoroacetic acid → HCID 22291467, compound

Participants

Reaction Steps

The title compound of Example 209 (1.96 g, 0.0033 mol) was dissolved in 6 mL CH2Cl2 and reacted with 5 mL TFA at room temperature for 36 h. The crude reaction mixture was diluted with CH2Cl2 and basified with a saturated aqueous solution of Na2CO3. The layers were separated and the organic layer was dried over MgSO4. The residue obtained after removal of the solvent under vacuum was triturated with EtOH to afford 0.503 g of title compound (yield: 32%). Mp: 265–267° C. 1H NMR (300 MHz, d6-DMSO): δ 2.88–2.95 (m, 4H), 6.12 (s, 2H), 5.58–6.62 (dd, 1H, J=7.6 Hz, 4.7 Hz), 6.97–7.08 (m, 4H), 7.17 (d, 1H, J=1.9 Hz), 7.28 (s, 1H), 7.32 (s, 2H), 7.55 (s, 2H), 7.95–7.98 (dd, 1H, J=7.7 Hz, 1.7 Hz), 8.11–8.13 (dd, 1H, J=4.7 Hz, 1.7 Hz), 9.99 (s, 1H). M+1=469.

Provenance & Evidence