Clopyralid → HCID 22291830, compound

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Reaction Steps

The title compound was synthesized from 1.653 g of 3,6-dichloro-2-pyridine carboxylic acid (CP92740, prepared by the method of E. Marzi, A. Bigi, M. Schlosser, Eur. J. Org. Chem. 2001, 1371–1376) and the title compound of step 4 of Example 161 (2.0 g) by the same procedure used for Example 211. The title compound is a brown solid (2.4 g, 80%), m.p. 263–265° C. Its structure was confirmed by 1H NMR and LC/MS: 1H NMR (d6-DMSO): δ 2.82–3.01 (m, 4H)), 6.11 (s, 2H), 6.97–7.07 (m, 2H), 7.38 d, 1H, J=1 Hz), 7.81 (s, 1H), 7.33–7.42 (m, 3H), 7.52 (s, 1H), 7.51 (d, 1H, J=9 Hz), 8.15 (d, 1H, J=9 Hz), 10.57 (s, 1H). ESI mass spectrum for C25H18Cl2N5O4+: 522 (M+1).

Provenance & Evidence