1-Methylhomopiperazine → HCID 22291682, compound

Participants

Reaction Steps

The title compound was synthesized by the same procedure as in Example 214 starting with the title compound of Example 248 (1 g, 0.0020 mol) and 1-methylhomopiperazine (4.6 g, 0.040 mol). The reaction was run at 95° C. for 24 h. After allowing the reaction mixture to cool, the volatiles were removed under vacuum. The residue was triturated with H2O to yield 0.899 g of the title compound as a tetrahydrate (yield: 71%). 1H NMR (300 MHz, d6-DMSO): δ 1.81–1.83 (m, 2H), 2.21 (s, 3H), 2.41 (t, 2H, J=5.5 Hz), 2.53 (t, 2H, J=4.56 Hz), 2.87–2.93 (m, 4H), 3.53 (t, 2H, J=5.5 Hz), 3.63–3.67 (m, 2H), 6.62 (s, 1H), 7.19 (d, 1H, J=1.9 Hz), 7.27–7.38 (m, 4H), 7.42–7.45 (dd, 1H, J=8.12 Hz, 1.88 Hz), 7.53–7.58 (m, 3H), 8.07 (s, 1H), 10.31 (s, 1H). M+1=575.

Provenance & Evidence