Aluminium lithium hydride → HCID 18438076, compound

Participants

Reaction Steps

4-Butyl-5-phenyl-4H-[1,2,4]triazole-3-carboxylic acid butyl ester (169) (1.38 g, 5 mmol) is taken up in 50 ml anhydrous THF. LAH is added (3 eq.). The reaction is refluxed for 12 hours and then quenched carefully with water. Purification by column with 2.5% MeOH/DCM gives the desired product (170). 1HNMR(CDCl3): δ=7.40–7.60(5H, m, phenyl-H), 4.88(2H, s, —CH2OH), 4.26(1H, br, —OH), 4.10(2H, t, J=7.8 Hz, —CH2—), 1.58–1.70(2H, m, —CH2—), 1.08–1.30(2H, m, —CH2—), 0.82(3H, t, J=7.5 Hz, —CH3)

Provenance & Evidence