HCID 20741395, compound → HCID 20741396, compound

HRID 457409Notes

Reaction equation

HRID 457409 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C@@H:15]1[CH2:19][CH2:18][N:17](C(OCC2C=CC=CC=2)=O)[CH2:16]1)[C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[C].[Pd].C(O)C>[C:1]([O:5][C:6]([NH:8][CH:9]([C@@H:15]1[CH2:19][CH2:18][NH:17][CH2:16]1)[C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 20741395HCID 20741395, compound

Product 1

HCID 20741396HCID 20741396, compoundYield 106.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

An ethanol (10 ml) solution of 3-(R)-[1-tert-butoxycarbonylamino-1-(2-furyl)methyl]-1-benzyloxycarbonylpyrrolidine [F1] (507 mg, 1.37 tool) was mixed with 10% palladium-carbon catalyst (53.8% moisture, 500 mg), and catalytic hydrogenation was carried out at room temperature for 4 hours under ordinary pressure. The reaction solution was filtered and the solvent of the filtrate was evaporated under a reduced pressure to obtain 358 mg of the crude title compound as colorless crystals. This was used in the subsequent reaction without purification.

Workup

  1. filtrationThe reaction solution was filtered
  2. customthe solvent of the filtrate was evaporated under a reduced pressure

Sources & evidence

ORD record
ord-01523eddd13e48168cafeb338bfa4425
Source dataset
uspto-grants-2007_03
Patent number
US07186843B2

Reaction notes

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