Benzoyl Peroxide → HCID 18439592, compound

Participants

Reaction Steps

30.75 g (0.12 mol) of methyl 2-methyl-3-fluoro-4-methylsulfonylbenzoate were introduced in 600 ml of CCl4. 35.5 g (0.2 mol) of N-bromosuccinimide and 0.86 g (0.002 mol) of benzoyl peroxide were mixed. A third of the amount is added at RT. Then the batch is heated to reflux and “irradiated”. Over the course of an hour the remaining NBS/benzoyl peroxide mixture is added in portions, followed by stirring under reflux for 2 h more. The batch is allowed to cool and is washed with a 10% strength sodium hydrogen sulfite solution, and dried over MgSO4, and the organic phase is concentrated to completion.

Provenance & Evidence