Sodium Hydroxide → HCID 18439590, compound

HRID 457464Notes

Reaction equation

HRID 457464 reaction equation
[CH3:1][S:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11]C)=[O:10])=[C:7]([CH2:15][S:16][CH3:17])[C:6]=1[F:18])(=[O:4])=[O:3].[OH-].[Na+]>CO>[CH3:1][S:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([OH:11])=[O:10])=[C:7]([CH2:15][S:16][CH3:17])[C:6]=1[F:18])(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18439593HCID 18439593, compound

Product 1

HCID 18439590HCID 18439590, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

20 g (0.07 mol) of methyl 4-methylsulfonyl-3-fluoro-2-methylthiomethylbenzoate were dissolved in 400 ml of methanol, and 10.95 g (0.27 mol) of a 2N NaOH solution were added. The solution was stirred at RT for 4 h. The methanol was removed. The residue was taken up in water and acidified with 2N HCl. This was followed by extraction with CH2Cl2 and the organic phase was dried over MgSO4 and concentrated to completion.

Workup

  1. customThe methanol was removed
  2. extractionThis was followed by extraction with CH2Cl2
  3. dry with materialthe organic phase was dried over MgSO4
  4. concentrationconcentrated to completion

Sources & evidence

ORD record
ord-27f8d717c45f4825a9b8723aebccced9
Source dataset
uspto-grants-2007_03
Patent number
US07189679B2

Reaction notes

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