1,2-Dichloroethane → HCID 13832665, compound

Participants

Reaction Steps

Vorbr□ggen coupling To the appropriate silylated base (12.9 mmol) was added the appropriate ribose (10.3 mmol) in 15 ml dry 1,2-dichloroethane. The residue was co-evaporated twice with dry 1,2-dichloroethane and subsequently dissolved in 75 ml dry 1,2-dichloroethane. The solution was gently refluxed and after 5 minutes trimethylsilyl-trifluoromethane sulfonate (TMS triflate) (997 □l, 5.16 mmol) was added. The mixture was refluxed for 2 hr, cooled to room temperature and diluted with CH2Cl2. It was extracted with 5% NaHCO3 and water. The organic layer was dried (MgSO4), concentrated and purified by column chromatography.

Provenance & Evidence