Potassium Carbonate → 1-(2-Chloro-4-nitrophenyl)-4-methylpiperazine

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1-Methylpiperazine	HCID 53167	—
Reactant	2-Chloro-1-fluoro-4-nitrobenzene	HCID 67688	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Product	1-(2-Chloro-4-nitrophenyl)-4-methylpiperazine	HCID 2837294	84%

Reaction Conditions

Temperature	100 °C

Reaction Steps

3-Chloro-4-fluoronitrobenzene (2.0 g, 11.4 mmol) was added to a stirred suspension of K2CO3 (1.6 g, 11.4 mmol) and N-methylpiperazine (1.3 mL, 1.17 g, 11.4 mmol) in dry DMSO (8 mL) and was heated at 100° C. for 1 h. The reaction was cooled to about 50° C. and poured into ice water (300 mL). The solid was collected by filtration, washed with water, and dried under vacuum to afford the title compound (2.43 g, 84%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07189712B2
Source dataset	uspto-grants-2007_03
ORD ID	ord-b62aa475132247bdb881e36c709b560d
Source note	uspto-grants-2007_03