4-[4-(1,4,7-Trioxaoct-1-yl)phenyl]butylamine → 4-[4-(1,4,7,10,13-Pentoxatetradec-1-yl)phenyl]butylamine

Participants

Reaction Steps

This compound was prepared in a similar fashion to the synthesis of amine 107 from compound 110 (385 mg, 0.78 mmol) to give 266 mg (95%) of compound 111. 1H NMR (300 MHz, CDCl3) δ 1.41–1.54 (m, 2H), 1.60 (br. s, 2H), 2.56 (t, J=7.5 Hz, 2H), 2.70 (t, J=7.0 Hz, 2H), 3.37 (s, 3H), 3.51–3.58 (m, 2H), 3.60–3.77 (m, 10H), 3.84 (m, 2H), 4.10 (t, 5.5 Hz, 2H), 6.83 (d, J=8.3 Hz, 2H), 7.07 (d, J=8.7 Hz, 2H).

Provenance & Evidence