Benzylamine → HCID 11471166, compound

HRID 457692Notes

Reaction equation

HRID 457692 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][CH3:12])=[C:4]([NH2:13])[N:3]=1.[CH2:14]([NH2:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([NH:21][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][CH3:12])=[C:4]([NH2:13])[N:3]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 232737382-Chloro-9-ethyl-9H-purin-6-amine

Product 1

HCID 11471166HCID 11471166, compound

Procedure

A mixture of 2-chloro-9-ethyl-9H-purin-6-ylamine (0.2 g, 1.01 mmol), a compound of formula (3), and 3 mL of benzylamine was heated in a steel bomb at 130° C. for 24 hours. The amine was removed from the reaction mixture by evaporation under reduced pressure, and the residue was chromatographed on a silica gel column, eluting with chloroform/methanol (95:5), to give pure 2-benzylamino-9-ethyl-9H-purin-6-ylamine, a compound of formula (4).

Workup

  1. customThe amine was removed from the reaction mixture by evaporation under reduced pressure
  2. customthe residue was chromatographed on a silica gel column
  3. washeluting with chloroform/methanol (95:5)

Sources & evidence

ORD record
ord-566088768024473785067e563439178c
Source dataset
uspto-grants-2007_03
Patent number
US07189730B2

Reaction notes

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