反应详情

A mixture of 2-chloro-9-ethyl-9H-purin-6-ylamine (0.2 g, 1.01 mmol), a compound of formula (3), and 3 mL of benzylamine was heated in a steel bomb at 130° C. for 24 hours. The amine was removed from the reaction mixture by evaporation under reduced pressure, and the residue was chromatographed on a silica gel column, eluting with chloroform/methanol (95:5), to give pure 2-benzylamino-9-ethyl-9H-purin-6-ylamine, a compound of formula (4).

1. customThe amine was removed from the reaction mixture by evaporation under reduced pressure
2. customthe residue was chromatographed on a silica gel column
3. washeluting with chloroform/methanol (95:5)