反应详情

温度

85 °C

To a mixture of 2-chloro-9-ethyl-9H-purin-6-ylamine (0.2 g, 1.01 mmol), a compound of formula (3), and dry sodium hydroxide (5 mmol) was added benzyl alcohol (9.0 mmol). This mixture was heated at 85° C. for 3 hours. The solvent was then removed under reduced pressure and the residue was neutralized with 2N HCl and extracted with CHCl3. The organic layer was dried (Na2SO4) and concentrated in vacuo. The residue was chromatographed on a silica gel column eluting with a mixture of ethyl acetate/cyclohexane/methanol (60/33/5) to give 2-benzyloxy-9-ethyl-9H-purin-6-ylamine as a chromatographically pure solid.

1. customThe solvent was then removed under reduced pressure
2. extractionextracted with CHCl3
3. dry with materialThe organic layer was dried (Na2SO4)
4. concentrationconcentrated in vacuo
5. customThe residue was chromatographed on a silica gel column
6. washeluting with a mixture of ethyl acetate/cyclohexane/methanol (60/33/5)