Hydrochloric Acid → HCID 18440618, compound

Participants

Reaction Steps

A mixture of 2-iodo-9-ethyl-9H-purin-6-ylamine (0.2 g, 0.69 mmol), 3 mL of benzyl mercaptan, and solid sodium hydroxide (200 mg, 5.0 mmol) was heated in a steel bomb at 100° C. for 24 hours. The reaction mixture was neutralized with 1N HCl and partitioned between water and chloroform. The organic layer was dried (Na2SO4), filtered and concentrated in vacuo, and the residue chromatographed on a silica gel column, eluting with a mixture of chloroform/methanol (97:3), to give 2-benzylthio-9-ethyl-9H-purin-6-ylamine, a compound of formula (4), as a chromatographically pure solid.

Provenance & Evidence