2-(Tributylstannyl)furan → HCID 10172251, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-phenylethylamino)-8-bromo-9-ethyl-9H-purin-6-ylamine (0.28 mmol), tributylstannyl furan (440 μL, 1.4 mmol), and bis(triphenylphosphine)palladium dichloride (12 mg, 0.017 mmol) was dissolved in dry tetrahydrofuran (10 mL), and heated at 60° C. for 3 hours. The solvent was removed in vacuo, and the residue was partitioned between water and chloroform. The organic layer was dried (Na2SO4), filtered and concentrated in vacuo. The residue was dissolved in CHCl3/MeOH and extracted with chloroform. The organic layers were dried over Na2SO4 and concentrated in vacuo. The residue was chromatographed on a silica gel column eluting with ethyl acetate/cyclohexane/methanol (60/36/4) to give 2-(2-phenylethylamino)-8-(furan-2-yl)-9-ethyl-9H-purin-6-ylamine as a chromatographically pure solid.

Provenance & Evidence