HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 45770Generated: October 25, 2026
Sodium Hydroxide → 2-(2-(4-Cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid
https://huagongshe.com/reaction/45770
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate | HCID 67997044 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2-(4-Cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid | HCID 67997363 | 96.6% |
Reaction Steps
A mixture of ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate (0.137 g, 0.42 mmol), aqueous sodium hydroxide solution (1M, 1 mL) and methanol (2 mL) was stirred at 60° C. for 12 hours. The reaction mixture was concentrated to remove methanol, acidified and filtered to obtain 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoic acid as a white powder (0.121 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08541589B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-e30259cea20948ec883382f0cd1979b7 |
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| Source note | uspto-grants-2013_09 |
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