Acetonitrile → HCID 86600096, compound

Participants

Reaction Steps

Intermediate 13a (250 mg) was added to a solution of intermediate 5b (449 mg) in anhydrous acetonitrile (9 mL) under a Nitrogen atmosphere. The solution was stirred at r.t. for 1 hour, then sodium triacetoxyborohydride (282 mg) was added. The mixture was stirred at 23° C. for 16 hours. The solution was diluted with a 5% sodium hydrogen carbonate solution (10 mL) and extracted with AcOEt (3×30 mL). The combined organic extracts were washed with brine (10 mL), dried and concentrated in vacuo to a residue which was purified by flash chromatography (AcOEt/MeOH 8:2) to give three fractions:

Provenance & Evidence