HCID 10407380, compound → HCID 69273945, compound

HRID 457732Notes

Reaction equation

HRID 457732 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:14][C@H:13]3[N:15]([CH3:16])[C@H:10]([CH2:11][CH2:12]3)[C@H:9]2[C:17]2[O:18][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[N:20][N:21]=2)=[CH:4][CH:3]=1>C(Cl)(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:14][C@H:13]3[N:15]([CH3:16])[C@H:10]([CH2:11][CH2:12]3)[C@H:9]2[C:17]2[O:18][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[N:20][N:21]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 10407380HCID 10407380, compound

Product 1

HCID 69273945HCID 69273945, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Further elution gave as a second fraction 0.1 g (13%) of white solid which was characterized to be 3β-(4-Chlorophenyl)-2β-(5-phenyl-1,3,4-oxadiazol-2-yl)-tropane: 1H NMR (CDCl3) 1.76 (m, 3H), 2.06 (s, 3H), 2.45 (s, 3H), 3.36 (m, 2H), 3.51 (m, 1H), 3.65 (m, 1H), 7.21 (m, 4H), 7.47 (m, 3H) 7.91 (m, 2H); mp 170–171° C.; Anal calcd for C22H22CIN3O; C=69.55; H=5.84, N=11.06; Cl=9.33; found C=69.49, H=5.85, N=11.01; Cl=9.41; [α]D +33.06° (c=0.18, CHCl3)

Sources & evidence

ORD record
ord-79252cd1889041528aa59bd03df74365
Source dataset
uspto-grants-2007_03
Patent number
US07189737B2

Reaction notes

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