Sulfuric Acid → HCID 10181111, compound

Participants

Reaction Steps

A cooled solution of sulphuric acid (9.8 g) in ethanol (100 cm3) was mixed into an ethanol solution of 3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione (AGN 2979) (33.25 g). Substantially immediately after mixing, the solvent was evaporated under reduced pressure and the residue recrystallised from ethanol to yield AGN 2979 bisulphate as crystals having a melting point of 164° C. After storage for a prolonged period in a non-air tight container, a sample had a portion which melted at 110° C. but the bulk of the sample melted at 164° C., indicating the presence of a hydrate.

Provenance & Evidence