Acetone → HCID 69421884, compound

Participants

Reaction Steps

A mixture of 4-benzylpiperidinyl-benzimidazole-5-carboxamide (318 mg, 1 mMol), solid KOH (280 mg, 5 mMol) and 2-iodopropane (1 g, 6 mMol) was refluxed in 20 mL acetone for 20 h. After the removal of acetone in vacuo, the residue was extracted from water with methylene chloride (3×50 mL). The combined extract was dried, evaporated and chromatographed to yield 180 mg (50%) of the desired product. 1HNMR (CDCl3): δ=7.7 (s, 1H); 7.4–7.1 (m, 7H); 4.8–4.6 (m, 1H); 3.0–2.7 (br, m, 4H); 2.6 (d, 2H); 1.8–1.45 (m, 3H); 1.5 (d, 6H); 1.3–1.1 (m, 2H). MS (ESI) m/e 360 (M).

Provenance & Evidence