2-Chloro-5-(chloromethyl)thiophene → HCID 11327120, compound

HRID 457787Notes

Reaction equation

HRID 457787 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[Cl:21][C:22]1[S:23][C:24]([CH2:27]Cl)=[CH:25][CH:26]=1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:27][C:24]3[S:23][C:22]([Cl:21])=[CH:26][CH:25]=3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 11380267Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate

Product 1

HCID 11327120HCID 11327120, compound

Procedure

This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 3.5 g (13 mmol) of 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 1.9 mL (16 mmol) of 2-chloro-5-chloromethyl-thiophene. After standard work-up, 5.2 g (99% of yield) of the expected product was obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0bd4e19ef896467dbbae05a0b6b987da
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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