2-(2-Bromoethyl)-1,3-dioxolane → HCID 69412997, compound

HRID 457793Notes

Reaction equation

HRID 457793 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Br[CH2:22][CH2:23][CH:24]1[O:28][CH2:27][CH2:26][O:25]1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:22][CH2:23][CH:24]3[O:28][CH2:27][CH2:26][O:25]3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 877762-(2-Bromoethyl)-1,3-dioxolaneHCID 11380267Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate

Product 1

HCID 69412997HCID 69412997, compoundYield 94.9%

Procedure

This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 4 g (0.015 mol) of 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 2.07 mL (0.018 mol) of 2-(2-bromo-ethyl)-[1,3]dioxolane. After standard work-up, 5.3 g of 4-[1-(2-[1,3]dioxolan-2-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b0d776f98f7c446586efafe64147cfe3
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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