2-(2-Bromoethyl)-1,3-dioxolane → 4-[1-(2-[1,3]dioxolan-2-yl-ethyl)-6-fluoro-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester

Participants

Reaction Steps

This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.1 g (0.37 mmol) of 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 0.081 g (0.45 mmol) of 2-(2-bromo-ethyl)-[1,3]dioxolane. 0.170 g (quantitative yield) of 4-[1-(2-[1,3]dioxolan-2-yl-ethyl)-6-fluoro-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Provenance & Evidence