HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Piperidinyl)-1H-indole → 5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Piperidinyl)-1H-indole | HCID 702235 | — |
| Reactant | 5-Bromomethyl-2-methoxybenzoic acid ethyl ester | HCID 68893946 | — |
| Product | 5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid ethyl ester | HCID 69412208 | 70% |
Reaction Steps
This compound was prepared following the procedure described in example 1 (part D) starting with 0.2 g (1 mmol) of 3-piperidin-4-yl-1H-indole and 0.34 g (1.3 mmol) 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After ionic exchange purification, 0.273 g (70% of yield) of 5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid ethyl ester were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07189741B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-8de74b28ca4b4b99b159b02ba3bbf956 |
| Source note | uspto-grants-2007_03 |