3-(Chloromethyl)pyridine hydrochloride → HCID 17964328, compound

HRID 457805Notes

Reaction equation

HRID 457805 reaction equation
C[O:2][C:3](=[O:28])[C:4]1[CH:9]=[C:8]([CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:13][CH2:12]2)[CH:7]=[CH:6][C:5]=1[O:26][CH3:27].Cl.Cl[CH2:31][C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1>>[CH3:27][O:26][C:5]1[CH:6]=[CH:7][C:8]([CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]([CH2:31][C:32]4[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=4)[CH:18]=3)[CH2:13][CH2:12]2)=[CH:9][C:4]=1[C:3]([OH:2])=[O:28]

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 69411705HCID 69411705, compound

Product 1

HCID 17964328HCID 17964328, compound

Procedure

This compound was prepared following the procedure described in example 1 (part E) starting with 0.054 g (0.13 mmol) of 5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid methyl ester and 0.029 mg (0.16 mmol) of 3-chloromethyl-pyridine hydrochloride. After the described purification, 0.007 g (11% of yield) of the expected acid was obtained.

Workup

  1. customThis compound was prepared
  2. customAfter the described purification, 0.007 g (11% of yield) of the expected acid
  3. customwas obtained

Sources & evidence

ORD record
ord-9a371cac4ba64b578837b0d767cf0a9b
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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