3-(Chloromethyl)pyridine hydrochloride → HCID 10275231, compound

HRID 457809Notes

Reaction equation

HRID 457809 reaction equation
C([O:3][C:4](=[O:28])[C:5]1[CH:10]=[C:9]([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[NH:20][CH:19]=3)[CH2:14][CH2:13]2)[CH:8]=[CH:7][C:6]=1[F:27])C.Cl.Cl[CH2:31][C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1>>[F:27][C:6]1[CH:7]=[CH:8][C:9]([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH2:31][C:32]4[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=4)[CH:19]=3)[CH2:14][CH2:13]2)=[CH:10][C:5]=1[C:4]([OH:3])=[O:28]

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 69411468HCID 69411468, compound

Product 1

HCID 10275231HCID 10275231, compound

Procedure

This compound was prepared following the procedure described in example 1 (part E) starting with 0.063 g (0.17 mmol) of 2-fluoro-5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-benzoic acid ethyl ester and 0.035 mg (0.21 mmol) of 3-chloromethyl-pyridine hydrochloride. After the described purification, 0.053 g (71% of yield) of the expected acid was obtained.

Workup

  1. customThis compound was prepared
  2. customAfter the described purification, 0.053 g (71% of yield) of the expected acid
  3. customwas obtained

Sources & evidence

ORD record
ord-bb10c02994d24b28a93f4a0707ef75fc
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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