HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Piperidinyl)-1H-indole → 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Piperidinyl)-1H-indole | HCID 702235 | — |
| Reactant | Ethyl 2-(bromomethyl)pyridine-3-carboxylate | HCID 825758 | — |
| Product | 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester | HCID 69411779 | 92.4% |
Reaction Steps
This compound was prepared following the procedure described in example 1 (part D) starting with 0.5 g (2.5 mmol) of 3-piperidin-4-yl-1H-indole and 0.65 g (3.25 mmol) of 2-bromomethyl-nicotinic acid ethyl ester. After the standard purification, 0.84 g (92% of yield) of 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07189741B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-85e4af361a44410c8e77b8e15f557960 |
| Source note | uspto-grants-2007_03 |