2-Chloro-5-(chloromethyl)thiophene → HCID 10163021, compound

HRID 457814Notes

Reaction equation

HRID 457814 reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[C:25]4[C:20](=[CH:21][C:22]([F:26])=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:13][CH2:12]2)[CH:5]=1.[Cl:28][C:29]1[S:30][C:31]([CH2:34]Cl)=[CH:32][CH:33]=1>>[Cl:28][C:29]1[S:30][C:31]([CH2:34][N:19]2[C:20]3[C:25](=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)[C:17]([CH:14]3[CH2:13][CH2:12][N:11]([CH2:10][C:6]4[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=4)[C:3]([OH:2])=[O:27])[CH2:16][CH2:15]3)=[CH:18]2)=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 69412641HCID 69412641, compound

Product 1

HCID 10163021HCID 10163021, compound

Procedure

This compound was prepared following the procedure described in example 1 (part E) starting with 0.07 g (0.19 mmol) of 3-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]-benzoic acid methyl ester and 0.05 g (0.29 mmol) of 2-chloro-5-chloromethyl-thiophene. After standard purification, 0.01 g (10% of the yield) of the expected acid were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard purification, 0.01 g (10% of the

Sources & evidence

ORD record
ord-048bacdf50014799923cd5486819e452
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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