HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-fluoro-3-(piperidin-4-yl)-1H-indole → 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]2-methoxybenzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11096077 | — |
| Reactant | 5-Bromomethyl-2-methoxybenzoic acid ethyl ester | HCID 68893946 | — |
| Product | 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]2-methoxybenzoic acid ethyl ester | HCID 68894051 | 100.8% |
Reaction Steps
This compound was prepared following the procedure described in example 1 (part D) starting with 0.5 g (2.2 mmol) of 6-fluoro-3-piperidin-4-yl-1H-indole and 0.8 g (2.9 mmol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard purification, 0.91 g (100% of yield) of 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid ethyl ester were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07189741B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-4efe466eb9294745b8a8879d9002a50b |
| Source note | uspto-grants-2007_03 |