Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate → HCID 69413356, compound

HRID 457827Notes

Reaction equation

HRID 457827 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Cl[CH2:22][CH2:23][O:24][C:25]1[CH:33]=[CH:32][C:28]2[O:29][CH2:30][O:31][C:27]=2[CH:26]=1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:22][CH2:23][O:24][C:25]3[CH:33]=[CH:32][C:28]4[O:29][CH2:30][O:31][C:27]=4[CH:26]=3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 11380267Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylateHCID 21414365HCID 21414365, compound

Product 1

HCID 69413356HCID 69413356, compoundYield 60.1%

Procedure

This compound was prepared following the procedure described in example 13 (part B) starting with 11 g (40 mmol) of 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 9.6 g (48 mmol) of 5-(2-chloro-ethoxy)-benzo[1,3]dioxole. The mixture was stirred at room temperature for 18 hours. After standard work-up and purification, 10.5 g (60% of yield) of 4-{1-[2-(benzo[1,3]dioxol-5-yloxy)-ethyl]-1H-indol-3-yl}-piperidine-1-carboxylic acid ethyl ester were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-f73808fa91f04c9c90fd9408fae933b1
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

Loading…