Methyl 2-(2-chloroethoxy)benzoate → HCID 17964314, compound

HRID 457828Notes

Reaction equation

HRID 457828 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][CH2:11][CH2:12][N:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[C:15]([CH:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]4)=[CH:14]3)=[CH:9][C:4]=2[O:3][CH2:2]1.C[O:29][C:30](=[O:41])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH2:38][CH2:39]Cl>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][CH2:11][CH2:12][N:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[C:15]([CH:22]4[CH2:23][CH2:24][N:25]([CH2:39][CH2:38][O:37][C:32]5[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=5[C:30]([OH:41])=[O:29])[CH2:26][CH2:27]4)=[CH:14]3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 9837283Methyl 2-(2-chloroethoxy)benzoateHCID 17964383HCID 17964383, compound

Product 1

HCID 17964314HCID 17964314, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 2.3 g (6.2 mmol) of 1-[2-(benzo[1,3]dioxol-5-yloxy)-ethyl]-3-piperidin-4-yl-1H-indole and 1.5 g (7.1 mmol) of 2-(2-chloroethoxy)-benzoic acid methyl ester. After standard work-up and recrystallisation with methanol, 1.6 g (49% of yield) of the expected acid were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and recrystallisation

Sources & evidence

ORD record
ord-66e42844373f4c938df5bece79cdd8a8
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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