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2-(Bromomethyl)furan → 4-(1-furan-2-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Bromomethyl)furan | HCID 4603765 | — |
| 反応物 | Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate | HCID 11380267 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-(1-furan-2-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 11360143 | 100% |
反応手順
This compound was prepared following the procedure described in example 13 (part B) starting with 9.4 g (34.4 mmol) of 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 40 mL of (40 mmol) of a freshly prepared 1M solution in ethyl ether of 2-bromomethyl-furan. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 13.2 g (100% of yield) of 4-(1-furan-2-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189741B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-b84ae90248164416936669315bdb50ae |
| 出典メモ | uspto-grants-2007_03 |