HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(bromomethyl)benzoate → 3-[4-(1-furan-2-ylmethyl-1H-indol-3-yl)piperidin-1-ylmethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(bromomethyl)benzoate | HCID 517981 | — |
| Reactant | 1-furan-2-ylmethyl-3-piperidin-4-yl-1H-indole | HCID 11208268 | — |
| Product | 3-[4-(1-furan-2-ylmethyl-1H-indol-3-yl)piperidin-1-ylmethyl]benzoic acid | HCID 10273238 | — |
Reaction Steps
This compound was prepared following the procedure described in example 13 (part D) starting with 2.8 g (10 mmol) of 1-furan-2-ylmethyl-3-piperidin-4-yl-1H-indole and 2.5 g (11 mmol) of 3-bromomethyl-benzoic acid methyl ester. After standard work-up, 1.5 g (36% of yield) of the expected acid were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07189741B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-7204b0d2a86045ec846fdae607197ca1 |
| Source note | uspto-grants-2007_03 |