Methyl 2-(2-chloroethoxy)benzoate → 2-(2-(4-(1-(2-(1,4-dioxan-2-yl)ethyl)-1H-indol-3-yl)piperidin-1-yl)ethoxy)benzoic acid

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Reaction Steps

This compound was prepared following the procedure described in example 13 (part D) starting with 0.58 g (1.84 mmol) of 1-(2-[1,4]dioxan-2-yl-ethyl)-3-piperidin-4-yl-1H-indole (example 71, part B) and 0.51 g (2.39 mmol) of 2-(2-chloro-ethoxy)-benzoic acid methyl ester. After standard work-up and purification by flash chromatography over silica gel, 0.18 g (20% of yield) of the expected acid were obtained.

Provenance & Evidence