HCID 17964301, compound → HCID 10114407, compound

HRID 457840Notes

Reaction equation

HRID 457840 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[CH:8]2)=[CH:2]1.C([O:24][C:25](=[O:36])[C:26]1[CH:31]=[C:30]([CH2:32]Br)[CH:29]=[CH:28][C:27]=1[O:34][CH3:35])C>>[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH:16]3[CH2:21][CH2:20][N:19]([CH2:32][C:30]4[CH:29]=[CH:28][C:27]([O:34][CH3:35])=[C:26]([CH:31]=4)[C:25]([OH:36])=[O:24])[CH2:18][CH2:17]3)=[CH:8]2)=[CH:2]1

Participants

3

Reactant 2

HCID 17964301HCID 17964301, compoundHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Product 1

HCID 10114407HCID 10114407, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 1.9 g (6.5 mmol) of 1-furan-3-ylmethyl-3-piperidin-4-yl-1H-indole and 1.9 g (7.1 mmol) 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard work-up, 1.2 g (42% of yield) of the expected acid were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-25a81bc64377416b8420180465d17e07
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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