HCID 11278467, compound → HCID 17964365, compound

HRID 457857Notes

Reaction equation

HRID 457857 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:7][N:8]2[CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1.Cl[CH2:24][CH2:25][O:26][C:27]1[CH:35]=[CH:34][CH:33]=[CH:32][C:28]=1[C:29]([OH:31])=[O:30]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:17]3[CH2:18][CH2:19][N:20]([CH2:24][CH2:25][O:26][C:27]4[CH:35]=[CH:34][CH:33]=[CH:32][C:28]=4[C:29]([OH:31])=[O:30])[CH2:21][CH2:22]3)=[CH:7][N:8]2[CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11278467HCID 11278467, compoundHCID 23444941HCID 23444941, compound

Product 1

HCID 17964365HCID 17964365, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 0.1 g (0.33 mmol) of 6-fluoro-3-piperidin-4-yl-1-thiophen-2-ylmethyl-1H-indole (example 82, part B) and 0.092 g (0.42 mmol) 2-(2-chloro-ethoxy)-benzoic acid acid methyl ester. The crude mixture was purified by HPLC-MS using a C-18 column.

Workup

  1. customThis compound was prepared
  2. customThe crude mixture was purified by HPLC-MS

Sources & evidence

ORD record
ord-512e1fc81c22484483f7ac732c826c9d
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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