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3-(Bromomethyl)thiophene → 4-(6-fluoro-1-thiophen-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Bromomethyl)thiophene | HCID 520703 | — |
| 反応物 | 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 11323738 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-(6-fluoro-1-thiophen-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 69411539 | 100% |
反応手順
This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.1 g (0.34 mmol) of 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 0.77 mL (0.45 mmol) of a freshly prepared 0.58 M solution of 3-bromomethylthiophene in ethyl ether. After standard work-up, 0.13 g (100% of yield) 4-(6-fluoro-1-thiophen-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189741B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-6ec9ecf4ffd047f996745d969ff3d529 |
| 出典メモ | uspto-grants-2007_03 |