Methyl 2-(2-chloroethoxy)benzoate → HCID 17964303, compound

HRID 457860Notes

Reaction equation

HRID 457860 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:7][N:8]2[CH2:11][C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)=[CH:4][CH:3]=1.C[O:24][C:25](=[O:36])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[O:32][CH2:33][CH2:34]Cl>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:17]3[CH2:22][CH2:21][N:20]([CH2:34][CH2:33][O:32][C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[C:25]([OH:36])=[O:24])[CH2:19][CH2:18]3)=[CH:7][N:8]2[CH2:11][C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 9837283Methyl 2-(2-chloroethoxy)benzoateHCID 17964295HCID 17964295, compound

Product 1

HCID 17964303HCID 17964303, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 0.98 g (0.31 mmol) of 6-fluoro-3-piperidin-4-yl-1-thiophen-3-ylmethyl-1H-indole (example 108, part B) and 0.09 g (0.40 mmol) 2-(2-chloro-ethoxy)-benzoic acid methyl ester. The crude mixture was purified by HPLC-MS using a C-18 column.

Workup

  1. customThis compound was prepared
  2. customThe crude mixture was purified by HPLC-MS

Sources & evidence

ORD record
ord-8d7f5c8aa5754591bf4f494b7c48575b
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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