HCID 11229939, compound → HCID 17964379, compound

HRID 457863Notes

Reaction equation

HRID 457863 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:17]=[CH:16][S:15][CH:14]=1)[CH:7]=[C:6]2[CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.C([O:26][C:27](=[O:38])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH2:35][CH2:36]Cl)C>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:17]=[CH:16][S:15][CH:14]=1)[CH:7]=[C:6]2[CH:18]1[CH2:23][CH2:22][N:21]([CH2:36][CH2:35][O:34][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[C:27]([OH:38])=[O:26])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 11229939HCID 11229939, compoundHCID 17964311HCID 17964311, compound

Product 1

HCID 17964379HCID 17964379, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 3.3 g (10 mmol) of 5-methoxy-3-piperidin-4-yl-1-thiophen-3-ylmethyl-1H-indole and 2.6 g (12 mmol) of 2-(2-chloro-ethoxy)-benzoic acid ethyl ester. After standard work-up and recrystallisation with ethanol, 1.8 g (37% of yield) of the expected acid were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and recrystallisation

Sources & evidence

ORD record
ord-94fa61edba3e4ce5ad345278d34cdef9
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

Loading…