Methyl 3-(bromomethyl)benzoate → HCID 17964330, compound

HRID 457866Notes

Reaction equation

HRID 457866 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([CH2:16][C:17]3[CH:21]=[CH:20][S:19][CH:18]=3)[CH:8]=2)[CH2:3][CH2:2]1.C[O:23][C:24](=[O:33])[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31]Br)[CH:26]=1>>[S:19]1[CH:20]=[CH:21][C:17]([CH2:16][N:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:7]([CH:4]3[CH2:5][CH2:6][N:1]([CH2:31][C:27]4[CH:26]=[C:25]([CH:30]=[CH:29][CH:28]=4)[C:24]([OH:33])=[O:23])[CH2:2][CH2:3]3)=[CH:8]2)=[CH:18]1

Participants

3

Reactant 2

HCID 517981Methyl 3-(bromomethyl)benzoateHCID 17964375HCID 17964375, compound

Product 1

HCID 17964330HCID 17964330, compound

Procedure

This compound was prepared following the procedure described in example 117 (part C) starting with 0.1 g (0.38 mmol) of 3-piperidin-4-yl-1-thiophen-3-ylmethyl-1H-indole and 0.1 g (0.48 mmol) of 3-bromomethyl-benzoic acid methyl ester. The crude mixture was purified by HPLC-MS using a C-18 column, and 0.005 g (98% of purity) of the expected acid were isolated.

Workup

  1. customThis compound was prepared
  2. customThe crude mixture was purified by HPLC-MS
  3. customwere isolated

Sources & evidence

ORD record
ord-cab950fe1e7e4d7f97046b12da3b44de
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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