3-Fluorobenzaldehyde → HCID 67073670, Verbindung

HRID 457870Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 457870
[Na].Cl.[N:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O>C(O)C>[F:12][C:13]1[CH:14]=[C:15]([CH:16]=[C:9]([C:6]2[CH:7]=[CH:8][N:3]=[CH:4][CH:5]=2)[C:10]#[N:11])[CH:18]=[CH:19][CH:20]=1

Komponenten

5

Edukt 3

HCID 680093-FluorobenzaldehydeHCID 5360545SodiumHCID 123966084-Pyridylacetonitrile hydrochloride

Produkt 1

HCID 67073670HCID 67073670, VerbindungAusbeute 56,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

After sodium (3.0 g, 130 mmol) was dissolved in ethanol (150 mL), 4-pyridyl acetonitrile hydrochloride (33 g, 121 mmol) was added thereto and stirred at room temperature. After 10 minutes, 3-fluorobenzaldehyde (8 g, 65 mmol) was added thereto and stirred as such for 30 minutes. The resulting precipitates were collected by filtration and washed with a small amount of water, to give the title compound (8.2 g, 56%) as a colorless solid.

Aufarbeitung

  1. stirringstirred as such for 30 minutes
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. washwashed with a small amount of water

Quellen und Nachweise

ORD-Eintrag
ord-7a3ce2111f244efdbaf6598c3bd4d546
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189717B2

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