Ammonium Chloride → 3-(Dimethylamino)-1-(furan-2-yl)-2-(pyridin-4-yl)prop-2-en-1-one

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Reaction Conditions

Reaction Steps

N,N-dimethylformamide dimethyl acetal (5 mL) was added to 1-(2-furyl)-2-(4-pyridyl)-1-ethanone (2.0 g, 10.7 mmol) and stirred at 100° C. for 2 hours. After cooling as it was, the reacton mixture was diluted with ethyl acetate and an aqueous saturated ammonium chloride solution. The aqueous layer was extracted with ethyl acetate (×6). The combined organic layer was dried over anhydrous sodium sulfate and concentrated, to give the title compound (2.5 g, 97%) as a reddish brown oil.

Provenance & Evidence