HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 457875Generated: November 3, 2026
Guanidine Hydrochloride → 4-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amine
https://huagongshe.com/reaction/457875
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Dimethylamino)-1-(furan-2-yl)-2-(pyridin-4-yl)prop-2-en-1-one | HCID 67073854 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amine | HCID 9794720 | 80% |
Reaction Steps
A suspension of 3-(dimethylamino)-1-(2-furyl)-2-(4-pyridyl)-2-propene-1-one (2.2 g, 9.08 mmol), guanidine hydrochloride (2.6 g, 27.2 mmol) and potassium carbonate (7.5 g, 54.3 mmol) in N,N-dimethylformamide (20 mL) was stirred at 70° C. for 12 hours. After cooling as it was, the reaction mixture was diluted with water. The resulting crystals were collected by filtration and washed with water, to give the title compound (1.73 g, 80%) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07189717B2 |
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| Source dataset | uspto-grants-2007_03 |
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| ORD ID | ord-6d8106a2920646acb514d843bfc9b85c |
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| Source note | uspto-grants-2007_03 |
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