Ethyl Acetate → HCID 9857771, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(3-fluorophenyl)-5-(4-pyridyl)-2-pyrimidinylamine (200 mg, 0.751 mmol) acetic anhydride (6 mL) and conc. sulfuric acid (4 drops) was stirred at 90° C. for 16 hours. After cooling as it was, the reaction solution was diluted with ethyl acetate, water and a saturated aqueous sodium bicarbonate solution. The organic layer was washed with saturated sodium bicarbonate (×2) and brine, and then dried over anhydrous sodium sulfate and concentrated. The residue was suspended in diethyl ether, and then the resulting solid was collected by filtration and washed with diethyl ether, to give the title compound (126 mg, 54%)

Provenance & Evidence