Ethanol → HCID 67975565, compound

HRID 45789Notes

Reaction equation

HRID 45789 reaction equation
[CH3:1][N:2]1[C:14]2[C:13]3[N:12]=[CH:11][N:10]=[CH:9][C:8]=3[CH2:7][CH2:6][C:5]=2[C:4]([C:15]([O:17]CC)=[O:16])=[N:3]1.C(O)C.[OH-].[K+:24]>>[CH3:1][N:2]1[C:14]2[C:13]3[N:12]=[CH:11][N:10]=[CH:9][C:8]=3[CH2:7][CH2:6][C:5]=2[C:4]([C:15]([O-:17])=[O:16])=[N:3]1.[K+:24]

Participants

4

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 67975569HCID 67975569, compound

Product 1

HCID 67975565HCID 67975565, compoundYield 80%

Procedure

The suspension of 440 mg (1.74 mmol) of ethyl 1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate in ethanol (30 ml) 300 mg (5.2 mmol) of potassium hydroxide was heated at reflux for 2 hours. The volatiles were removed under vacuum, the residue was diluted with ethanol (3 ml) and the solid filtered to provide potassium 1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate 374 mg (80%).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. customThe volatiles were removed under vacuum
  4. additionthe residue was diluted with ethanol (3 ml)
  5. filtrationthe solid filtered

Sources & evidence

ORD record
ord-41d0d88aa19e430d9a0d13dc625be95b
Source dataset
uspto-grants-2013_09
Patent number
US08541576B2

Reaction notes

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