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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 457912Generated: October 25, 2026

O-((4-Methoxyphenyl)methyl)hydroxylamine → Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid

https://huagongshe.com/reaction/457912

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-((4-Methoxyphenyl)methyl)hydroxylamineHCID 120426—
Reactant(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acidHCID 11593804—
Reactanttert-butoxycarbonyl-4-(methoxyimino)-2-Pyrrolidinecarboxylic acidHCID 72828956—
ProductTert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acidHCID 7387689985%

Reaction Steps

The same method as employed in the preparation of Intermediate 7, but starting from (2S)-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (Intermediate 1) and 1[(aminooxy)methyl]-4-methoxy-benzene (Intermediate 10) gave the title compound as a gum in a 85% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07189754B2
Source datasetuspto-grants-2007_03
ORD IDord-235e92cbb3e34fcf9cf44aa06c42ac6b
Source noteuspto-grants-2007_03