HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyrimidin-5-yl)benzoic acid → Methyl (2S,4EZ)-4-(methoxyimino)-1-[4-(5-pyrimidinyl)benzoyl]-2-pyrrolidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyrimidin-5-yl)benzoic acid | HCID 4187247 | — |
| Reactant | 1-tert-butyl 2-methyl (2S,4EZ)-4-(methoxyimino)-1,2-pyrrolidinedicarboxylate | HCID 58585478 | — |
| Product | Methyl (2S,4EZ)-4-(methoxyimino)-1-[4-(5-pyrimidinyl)benzoyl]-2-pyrrolidinecarboxylate | HCID 131726286 | 68% |
Reaction Steps
Following the general methods as outlined in Example 4, starting from 1-tert-butyl 2-methyl (2S,4EZ)-4-(methoxyimino)-1,2-pyrrolidinedicarboxylate and 4-(5-pyrimidinyl)benzoic acid, the title compound was obtained, after flash-chromatography, as a mixture of two isomers as an oil in 68% yield (93.0% purity by HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07189754B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-56442d9ec96e4ba293d62f7636dffbae |
| Source note | uspto-grants-2007_03 |