HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Methyl-2-pyridinyl)benzoic acid → Methyl (2S,4EZ)-4-(methoxyimino)-1-[4-(3-methyl-2-pyridinyl)benzoyl]-2-pyrrolidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Methyl-2-pyridinyl)benzoic acid | HCID 21937311 | — |
| Reactant | 1-tert-butyl 2-methyl (2S,4EZ)-4-(methoxyimino)-1,2-pyrrolidinedicarboxylate | HCID 58585478 | — |
| Product | Methyl (2S,4EZ)-4-(methoxyimino)-1-[4-(3-methyl-2-pyridinyl)benzoyl]-2-pyrrolidinecarboxylate | HCID 131726288 | 50% |
Reaction Steps
Following the general method as outlined in Example 4 (Method B), starting from 1-tert-butyl 2-methyl (2S,4EZ)-4-(methoxyimino)-1,2-pyrrolidinedicarboxylate and 4-(3-methyl-2-pyridinyl)benzoic acid, the title compound was obtained, after flash-chromatography (eluent cyclohexane/ethyl acetate 8:2), as a mixture of two isomers in 50% yield (100% purity by HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07189754B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-0d083749aaf94148b6d39fbf3be71131 |
| Source note | uspto-grants-2007_03 |