Methanol → Methyl (2S,4EZ)-1-[(2'-methoxy[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxylate

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	2'-Methoxy-biphenyl-4-carboxylic acid	HCID 2759548	—
Reactant	(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid	HCID 58714586	—
Product	Methyl (2S,4EZ)-1-[(2'-methoxy[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxylate	HCID 131726293	—

Reaction Steps

Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methoxy[1,1′-biphenyl]-4-carboxylic-acid, and methanol, the title compound was isolated as a mixture of two isomers in 92.1% purity by HPLC.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07189754B2
Source dataset	uspto-grants-2007_03
ORD ID	ord-782bf83c258b4d0f9df890a8b85aaa2a
Source note	uspto-grants-2007_03